Structure of PDB 8pku Chain B

Receptor sequence
>8pkuB (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
RLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLY
AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHI
YAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY
DGQDQLNSVERYDVATATWTFVAPMKHRRSALGITVHQGRIYVLGGYDGH
TFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPS
3D structure
PDB8pku Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
ChainB
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y334 S363 R380 N382 R415 R483 S508 G509 Y525 S555 Y572 F577 S602 Y9 S38 R55 N57 R90 R158 S183 G184 Y200 S230 Y247 F252 S277
External links
PDB RCSB:8pku, PDBe:8pku, PDBj:8pku
PDBsum8pku
PubMed37917529
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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