Structure of PDB 8pia Chain B

Receptor sequence

>8piaB (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]

PEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSH
LSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHARNRFKWGPASQQI
LFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVR
VYNWFANRRKEEA

3D structure

PDB

8pia Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.

Chain

Resolution

2.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	N140 S142 H143 Q146 P153 K158 F204 W206 R263 N270	N47 S49 H50 Q53 P60 K65 F91 W93 R150 N157
BS02	dna	B	P129 Q130 R131 Q141 S145 N149 R203 R272	P36 Q37 R38 Q48 S52 N56 R90 R159

External links

PDB	RCSB:8pia, PDBe:8pia, PDBj:8pia
PDBsum	8pia
PubMed	38855865
UniProt	P20823\|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)

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