Structure of PDB 8pd8 Chain B

Receptor sequence

>8pd8B (length=1018) Species: 7668 (Strongylocentrotus purpuratus)

AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVP
LVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILAL
FGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLG
ASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQV
AVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEV
SGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVV
VTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRN
AVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINA
TTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADA
DWDIATAACEISDPYSSPREFADMMEEARLRMLKAEKISYWKQFEHGMLA
REALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISH
HMAFEVTINIAIVLNIVPIIMEFVVQDKMLQKIEDALRISNYVFFVIYAI
EAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFRLL
RGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIID
RMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTI
LNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPEN
LLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGL
VKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDM
NIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLER
GYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHK
LTFQYTATEEPRLFVVRN

3D structure

• PDB: 8pd8 Structures of a sperm-specific solute carrier gated by voltage and cAMP.
• Chain: B
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CMP	B	L1008 F1032 G1043 M1045 G1046 R1053 N1054 A1055	L853 F859 G870 M872 G873 R880 N881 A882

Gene Ontology

Molecular Function

• GO:0015297 antiporter activity
• GO:0015385 sodium:proton antiporter activity

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0055085 transmembrane transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8pd8, PDBe:8pd8, PDBj:8pd8
• PDBsum: 8pd8
• PubMed: 37880361
• UniProt: A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)