Structure of PDB 8pau Chain B

Receptor sequence
>8pauB (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV
STLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT
GSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADF
GLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDV
HPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKM
LSHQLVSQPGLNRGLILDLLDKLKNP
3D structure
PDB8pau Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405
ChainB
Resolution2.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XOR B L23 G24 G25 Y28 V31 A44 M91 C94 D101 L144 L17 G18 G19 Y22 V25 A38 M85 C88 D95 L138
External links
PDB RCSB:8pau, PDBe:8pau, PDBj:8pau
PDBsum8pau
PubMed
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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