Structure of PDB 8p9i Chain B

Receptor sequence
>8p9iB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB8p9i Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB462
ChainB
Resolution1.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8T B K57 Q59 N117 K16 Q18 N76
BS02 X8T B W81 F83 V87 L92 N140 I146 W40 F42 V46 L51 N99 I105
External links
PDB RCSB:8p9i, PDBe:8p9i, PDBj:8p9i
PDBsum8p9i
PubMed38291964
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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