Structure of PDB 8p5l Chain B

Receptor sequence
>8p5lB (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ
TLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM
RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPANPNSIRV
KIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPAATSAPLRQLLLALLQR
NHKDRMDFDEFFHHPFLDA
3D structure
PDB8p5l Crystal structures of ULK1 in complex with KCGS compounds
ChainB
Resolution1.836 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FV B I22 H24 A44 K46 M92 Y94 C95 L145 I15 H17 A37 K39 M85 Y87 C88 L138
BS02 MG B E191 Y198 D199 H263 E180 Y187 D188 H252
BS03 MG B H136 D165 F166 F168 H129 D154 F155 F157
External links
PDB RCSB:8p5l, PDBe:8p5l, PDBj:8p5l
PDBsum8p5l
PubMed
UniProtO75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Gene Name=ULK1)

[Back to BioLiP]