Structure of PDB 8p5g Chain B

Receptor sequence
>8p5gB (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ
TLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM
RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNANPNSIRVK
IADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVY
QCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRN
HKDRMDFDEFFHHPFLD
3D structure
PDB8p5g Crystal structures of ULK1 in complex with KCGS compounds
ChainB
Resolution2.019 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XBJ B I22 G23 H24 A44 M92 C95 N96 G98 D99 Q142 L145 I15 G16 H17 A37 M85 C88 N89 G91 D92 Q135 L138
BS02 MG B E191 Y198 D199 H263 E179 Y186 D187 H251
BS03 MG B H136 D165 F166 F168 H129 D153 F154 F156
External links
PDB RCSB:8p5g, PDBe:8p5g, PDBj:8p5g
PDBsum8p5g
PubMed
UniProtO75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Gene Name=ULK1)

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