Structure of PDB 8owx Chain B

Receptor sequence
>8owxB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
SEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFTTREFEELR
SCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQ
NPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLV
LQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYF
FTDDFLAQLFMDTGYEEVVNEYVFRETVLCVPRVFLQSKFLKPPK
3D structure
PDB8owx Structural basis of the cooperation between the m3C RNA-methyltransferase METTL6 with SerRS amino-acyl-synthetase for tRNA recognition
ChainB
Resolution2.601 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B W45 Y49 G87 D110 F111 C135 D136 L137 I157 W30 Y34 G66 D89 F90 C114 D115 L116 I136
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0019899 enzyme binding
GO:0052735 tRNA (cytidine-3-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8owx, PDBe:8owx, PDBj:8owx
PDBsum8owx
PubMed38918637
UniProtQ8TCB7|METL6_HUMAN tRNA N(3)-methylcytidine methyltransferase METTL6 (Gene Name=METTL6)

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