Structure of PDB 8ow5 Chain B

Receptor sequence
>8ow5B (length=224) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HDMAGVKALVTAGGTREPLDPVRFIGNRSSGKQGYAVARVLAQRGADVTL
IAGNTAGLIDPAGVEMVHIGSATQLRDAVSKHAPDANVLVMAAAVADFRP
AHVAAAKIKKGASEPSSIDLVRNDDVLAGAVRARADGQLPNMRAIVGFAA
ETGDANGDVLFHARAKLERKGCDLLVVNAVGENRAFEDGWLLSADGTESA
LEHGSKTLMATRIVDSIAAFLKSQ
3D structure
PDB8ow5 Development of new inhibitors against M. tuberculosis CoaBC using a fragment based approach.
ChainB
Resolution2.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.36: phosphopantothenoylcysteine decarboxylase.
6.3.2.5: phosphopantothenate--cysteine ligase (CTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP B K291 K293 K294 K107 K109 K110
BS02 VEO B S213 G215 Q217 S29 G31 Q33
BS03 CTP B M275 A277 V279 D281 D309 V310 F332 K350 K354 M91 A93 V95 D97 D125 V126 F148 K166 K170
External links
PDB RCSB:8ow5, PDBe:8ow5, PDBj:8ow5
PDBsum8ow5
PubMed
UniProtA0QWT2|COABC_MYCS2 Coenzyme A biosynthesis bifunctional protein CoaBC (Gene Name=coaBC)

[Back to BioLiP]