Structure of PDB 8ow4 Chain B

Receptor sequence
>8ow4B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHHVGTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGA
VKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGK
TVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGE
TDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVER
QDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDK
SQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
3D structure
PDB8ow4 2.75 angstrom crystal structure of human NFAT1 with bound DNA
ChainB
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R421 G428 S429 R430 R537 Q571 R39 G46 S47 R48 R155 Q189
BS02 dna B Y424 T426 K520 R522 N523 R537 K538 R572 R665 Y42 T44 K138 R140 N141 R155 K156 R190 R283
BS03 dna B H383 H385 H388 H1 H3 H6
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ow4, PDBe:8ow4, PDBj:8ow4
PDBsum8ow4
PubMed
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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