Structure of PDB 8otw Chain B

Receptor sequence

>8otwB (length=833) Species: 7668 (Strongylocentrotus purpuratus)

HAHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNV
PLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILA
LFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDL
GASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQ
VAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLE
VSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGV
VVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWR
NAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVIN
ATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLAD
ADWDIATAACEISDPYSAREFADMMEEARLRMLKAEKISYWKQFEHGMLA
REALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISE
KKIAAIPMPKYKLGKLMYKICHHMAFEVTINIAIVLNIVPIIMEFVVQDK
SSLQKIEDALRISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILV
VALVDIIIAETLLKGSITINLSSIKVVKLFRLLRGLRMLRLTKALIPKLI
LVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISE
TGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLL
DEMEAHKLELTVEIKMKRLMNAPSSIPPPPPEN

3D structure

• PDB: 8otw Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger.
• Chain: B
• Resolution: 3.68 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CPL	B	M251 Q256 L257 N264 Y267 F268	M181 Q186 L187 N194 Y197 F198

Gene Ontology

Molecular Function

• GO:0015297 antiporter activity
• GO:0015385 sodium:proton antiporter activity

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0055085 transmembrane transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8otw, PDBe:8otw, PDBj:8otw
• PDBsum: 8otw
• PubMed: 37880360
• UniProt: A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)