Structure of PDB 8otv Chain B

Receptor sequence
>8otvB (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNS
SRRSLVLVKQFRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVT
VELCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVATYWSGVGLTG
SRQTMFYTEVTDAQRSGPLIEVVHLPLEGAQAFADDPDIPKTLGVIFGVS
WFLSQVAPNLD
3D structure
PDB8otv Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
ChainB
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.45: UDP-sugar diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W0O B Y17 L107 Y17 L107
BS02 W0O B W34 D35 L148 W34 D35 L148
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008768 UDP-sugar diphosphatase activity
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0006753 nucleoside phosphate metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019693 ribose phosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8otv, PDBe:8otv, PDBj:8otv
PDBsum8otv
PubMed38635563
UniProtO95848|NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (Gene Name=NUDT14)

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