Structure of PDB 8otl Chain B

Receptor sequence
>8otlB (length=266) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFRLRLIQRITDR
LPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGM
GINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSR
AMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIV
GGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPAT
TGDIIYADGGAHTQLL
3D structure
PDB8otl Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
ChainB
Resolution2.108 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G14 I16 S20 I21 F41 D64 V65 S94 I95 G96 I122 M147 D148 K165 A191 I194 T196 G12 I14 S18 I19 F39 D61 V62 S91 I92 G93 I119 M144 D145 K162 A188 I191 T193
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0005504 fatty acid binding
GO:0016491 oxidoreductase activity
GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity
GO:0070403 NAD+ binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation
GO:0046677 response to antibiotic
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8otl, PDBe:8otl, PDBj:8otl
PDBsum8otl
PubMed38128204
UniProtP9WGR1|INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH] (Gene Name=inhA)

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