Structure of PDB 8oqr Chain B

Receptor sequence
>8oqrB (length=727) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GSSHHHHMPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVD
RLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIKR
QLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVT
LGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELVAT
VEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAILP
SFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVTG
QVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAYV
SAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLARI
TPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTSTL
PITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT
LAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQAG
YPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIEL
GRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFAE
ALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAGTG
KAAFVARARELAAAYGDRFLPPESLLS
3D structure
PDB8oqr Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VWT B T72 M73 A76 D80 V84 T79 M80 A83 D87 V91
BS02 VWT B G67 G68 D69 V70 M73 L114 G115 P140 E141 G74 G75 D76 V77 M80 L121 G122 P147 E148
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016491 oxidoreductase activity
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016829 lyase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009056 catabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oqr, PDBe:8oqr, PDBj:8oqr
PDBsum8oqr
PubMed39012716
UniProtO53872

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