Structure of PDB 8oqn Chain B

Receptor sequence
>8oqnB (length=728) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MGSSHHHHMPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAV
DRLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIK
RQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEV
TLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELVA
TVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAIL
PSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVT
GQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAY
VSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLAR
ITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTST
LPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDY
TLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQA
GYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIE
LGRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFA
EALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAGT
GKAAFVARARELAAAYGDRFLPPESLLS
3D structure
PDB8oqn Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W3U B Q252 L253 Q260 L261
BS02 W3U B I241 F245 N248 I249 F253 N256
BS03 W3U B P259 R262 Q294 P267 R270 Q302
BS04 W3U B M30 M73 V84 E141 M38 M81 V92 E149
BS05 W3U B F160 N164 S168 K180 F168 N172 S176 K188
BS06 W3U B S512 M560 I563 S520 M568 I571
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016491 oxidoreductase activity
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016829 lyase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009056 catabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oqn, PDBe:8oqn, PDBj:8oqn
PDBsum8oqn
PubMed39012716
UniProtO53872

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