Structure of PDB 8oma Chain B

Receptor sequence
>8omaB (length=577) Species: 9606 (Homo sapiens) [Search protein sequence]
MEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVT
QPLLKLREINARLDAVSEVLHSSSVFGQIENHLRKLPDIERGLCSIYHKK
CSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPV
EHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQE
IRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHS
PFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVD
CIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNT
DLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIV
DGIFTRMGAADNIYKGRSTFMEELTDTAEIIRKATSQSLVILDELGRGTS
THDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGF
LVSDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLI
NTKRKRLKYFAKLWTMHNAQDLQKWTE
3D structure
PDB8oma MutSbeta bound to 61bp homoduplex DNA
ChainB
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B I945 G948 S950 T951 I413 G416 S418 T419
BS02 ATP B I867 Y877 V878 N898 G900 G901 K902 S903 S904 E976 Y1057 I335 Y345 V346 N366 G368 G369 K370 S371 S372 E444 Y510
BS03 MG B S903 D975 S371 D443
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032139 dinucleotide insertion or deletion binding
GO:0032142 single guanine insertion binding
GO:0032181 dinucleotide repeat insertion binding
GO:0032357 oxidized purine DNA binding
GO:0042803 protein homodimerization activity
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006312 mitotic recombination
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043570 maintenance of DNA repeat elements
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0032302 MutSbeta complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oma, PDBe:8oma, PDBj:8oma
PDBsum8oma
PubMed
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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