Structure of PDB 8om9 Chain B

Receptor sequence
>8om9B (length=816) Species: 9606 (Homo sapiens) [Search protein sequence]
YTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDH
NFMTASIPTHRLFVHVRRLVAKGYKVGVVKQRKLTALYTKSTLIGEDVNP
LTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSE
LETRMSSLQPVELLLPSALSEQTEALIHRATSVRIRVERMDNIYFEYSHA
FQAVTEFYIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKME
FMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQP
LLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKC
STQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVE
HYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEI
RKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSP
FIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDC
IFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTD
LSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVD
GIFTRMSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYAT
LEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDFVTFLY
QITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYF
AKLWTMHNAQDLQKWT
3D structure
PDB8om9 MutSbeta bound to (CAG)2 DNA (open form)
ChainB
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H288 R289 V747 S748 K757 T774 K775 A776 R779 H60 R61 V464 S465 K474 T491 K492 A493 R496
BS02 dna B G253 Y254 Q309 R328 G25 Y26 Q81 R82
BS03 ADP B Q876 Y877 V878 N898 K902 S903 S904 Y1057 Q593 Y594 V595 N615 K619 S620 S621 Y750
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032139 dinucleotide insertion or deletion binding
GO:0032142 single guanine insertion binding
GO:0032181 dinucleotide repeat insertion binding
GO:0032357 oxidized purine DNA binding
GO:0042803 protein homodimerization activity
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006312 mitotic recombination
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043570 maintenance of DNA repeat elements
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0032302 MutSbeta complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8om9, PDBe:8om9, PDBj:8om9
PDBsum8om9
PubMed
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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