Structure of PDB 8om7 Chain B

Receptor sequence

>8om7B (length=776) Species: 9606 (Homo sapiens)

HLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDD
SNESDVVESLDEIEHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEM
VEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQ
RVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFEL
SKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR
ERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGK
YSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFY
GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGK
IIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDH
YLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAER
YLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRK
SAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTA
MGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFAR
AFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRP
VRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYD
LAAFITEGLEVHFVEHYREIFDIAFP

3D structure

• PDB: 8om7 Phosphorylation of the N-terminal domain of human mitochondrial Lon protease disrupts its functions
• Chain: B
• Resolution: 3.74 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.53: endopeptidase La.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	Y492 G526 V527 G528 T530 Y661 I669	Y320 G354 V355 G356 T358 Y489 I497

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0030163 protein catabolic process

External links

• PDB: RCSB:8om7, PDBe:8om7, PDBj:8om7
• PDBsum: 8om7
• PubMed: 38688959
• UniProt: P36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)