Structure of PDB 8oku Chain B

Receptor sequence
>8okuB (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
GSPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL
KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH
GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF
GFSNLFTPGQLLKDWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV
CGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLS
MEQICKHKWMKLGDADPNFDRLIAECQQPLNEDVLLAMEDMGLDKEQTLQ
SLRSDAYDHYSAIYSLLCDRHKRHK
3D structure
PDB8oku Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VRU B I72 V80 K95 T142 Y144 A145 S146 G148 N193 L195 A205 D206 I15 V23 K38 T85 Y87 A88 S89 G91 N136 L138 A148 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8oku, PDBe:8oku, PDBj:8oku
PDBsum8oku
PubMed38147525
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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