Structure of PDB 8oiv Chain B

Receptor sequence
>8oivB (length=285) Species: 10244 (Monkeypox virus) [Search protein sequence]
MDVVSLDKPFMYFEEIDNELDYEPEKLPYQGQLKLLLGELFFLSKLQRHG
ILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLR
DVTLVTRFVDEEYLRSIKKQLHPSKIILISDVRSKPSTADLLSNYALQNV
MISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLS
IYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVINFDYPNQEYDYFH
MYFMLRTVYCNKTFPTTKAKILFLQQSIFRFLNIP
3D structure
PDB8oiv Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
ChainB
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTG B Y22 R97 R140 S141 K142 P148 K175 R177 F180 D182 E233 Y22 R90 R133 S134 K135 P136 K163 R165 F168 D170 E221
BS02 SAH B L42 Y66 G68 S69 A70 P71 G72 H74 D95 R97 F115 V116 D138 V139 R140 L35 Y59 G61 S62 A63 P64 G65 H67 D88 R90 F108 V109 D131 V132 R133
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0006412 translation
GO:0006414 translational elongation
GO:0031440 regulation of mRNA 3'-end processing
GO:0032259 methylation
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oiv, PDBe:8oiv, PDBj:8oiv
PDBsum8oiv
PubMed37421984
UniProtA0A7H0DN74|MCE_MONPV Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (Gene Name=OPG102)

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