Structure of PDB 8oha Chain B

Receptor sequence
>8ohaB (length=336) Species: 267671 (Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130) [Search protein sequence]
GAMTRIAINGFGRIGRLVFRAGIKDPNLEFVAINDLVTPDNLAYLLKYDS
THGRFQGTVEHTEKELIVDGKKILCVSERDPEKLPWKDLKVDYVIESTGL
FTDRVGAEKHIKAGAKKVVISAPAKDKDIPTFVMGVNNEKYNPSNDHIVS
NASCTTNCLAPIVKVVLDNWGIEEGLMTTIHATTATQPTVDGPSKKDFRG
GRGAMQNIIPASTGAAKAVGLCIPEVNGKLTGMSFRVPTPDVSVVDLTVR
TTKETSLKEISAKMKAASEGAMKGILGYTEDMVVSNDFVSSTLSSIFDMD
ACIELNSRFFKLVSWYDNEMGYSNRVLDLIRYMAKK
3D structure
PDB8oha The structure of Leptospira interrogans GAPDH sheds light into an immunoevasion factor that can target the anaphylatoxin C5a of innate immunity.
ChainB
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.-
1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 B T182 R234 T184 R236
BS02 NAD B G8 G10 R11 I12 D33 L34 R77 S95 T96 S119 A152 N316 Y320 G10 G12 R13 I14 D35 L36 R79 S97 T98 S121 A154 N318 Y322
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8oha, PDBe:8oha, PDBj:8oha
PDBsum8oha
PubMed37409124
UniProtQ72QM3

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