Structure of PDB 8ogi Chain B

Receptor sequence
>8ogiB (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]
VDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN
QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP
FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLAT
ELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGH
YRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLS
SAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRR
IGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR
KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRF
WWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN
CSRIPRLNLSAWRGT
3D structure
PDB8ogi Posttranslational modification and heme cavity architecture of human eosinophil peroxidase-insights from first crystal structure and biochemical characterization
ChainB
Resolution1.547 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.7: peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEB B E380 T467 F470 R471 G473 H474 L477 F503 F545 L555 R562 E130 T217 F220 R221 G223 H224 L227 F253 F295 L305 R312
BS02 CA B T306 F308 D310 S312 T56 F58 D60 S62
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:8ogi, PDBe:8ogi, PDBj:8ogi
PDBsum8ogi
PubMed38229400
UniProtP11678|PERE_HUMAN Eosinophil peroxidase (Gene Name=EPX)

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