Structure of PDB 8og4 Chain B

Receptor sequence
>8og4B (length=710) Species: 9606 (Homo sapiens) [Search protein sequence]
SLPIRLLPEKLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFG
SYLDPLVKQAFQATARANVYVTENADIACLYVILVGEMQEPVVLRPAELE
KQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQ
YRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIADYDDRI
IATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLST
FALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWN
EAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNT
VLAMIRTRIQIPAAPIREEAAAEIPHRSGKETEPPYASPRYLRNFTLTVT
DFYRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGK
EFQAALGGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNS
PKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAILSIDDDAH
LRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPP
IKVTSRWTFDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLP
HDKTKCFKFI
3D structure
PDB8og4 Molecular mechanism of decision-making in glycosaminoglycan biosynthesis
ChainB
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA B D779 H782 D581 H584
BS02 MN B D744 D746 D546 D548
BS03 UDP B L668 Y670 R672 N723 L725 D744 D745 D746 L470 Y472 R474 N525 L527 D546 D547 D548
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0005515 protein binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0016500 protein-hormone receptor activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0045617 negative regulation of keratinocyte differentiation
GO:0050728 negative regulation of inflammatory response
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0106015 negative regulation of inflammatory response to wounding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000972 positive regulation of detection of glucose
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8og4, PDBe:8og4, PDBj:8og4
PDBsum8og4
PubMed37828045
UniProtO43909|EXTL3_HUMAN Exostosin-like 3 (Gene Name=EXTL3)

[Back to BioLiP]