Structure of PDB 8ofw Chain B

Receptor sequence
>8ofwB (length=342) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLAST
VFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAP
RLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPA
GDAVNDYRASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVR
AETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVATNTTVSRDGLTTP
GVDRLGPGGISGPPLAQRAVQVLRRLYDRVALISVGGIETADDAWERITA
GASLLQGYTGFIYGGERWAKDIHEGIARRLHDGEAVGSARRR
3D structure
PDB8ofw Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B A66 G67 K70 N115 N143 K212 S263 G264 V291 G292 G293 I294 G313 Y314 T315 A64 G65 K68 N113 N141 K210 S261 G262 V285 G286 G287 I288 G307 Y308 T309
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0106430 dihydroorotate dehydrogenase (quinone) activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ofw, PDBe:8ofw, PDBj:8ofw
PDBsum8ofw
PubMed37278160
UniProtP9WHL1|PYRD_MYCTU Dihydroorotate dehydrogenase (quinone) (Gene Name=pyrD)

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