Structure of PDB 8kgq Chain B

Receptor sequence
>8kgqB (length=1190) Species: 10497 (African swine fever virus) [Search protein sequence]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SISKKDNHKQVDVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTL
GKSNPSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNN
KVLQGIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLL
LAYFHLFWPQLIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKK
QTSLANHTVKYYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIY
FGGESELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDA
IERQIPNFLDGMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYH
HGDMSLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYIS
VQLASEFIKTMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANP
SEGWKYTTWARQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPS
NYNFKGHLKRFGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKK
SSNRMTFIEEIIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENF
LRLRNCLHSHLNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHA
VLKLRIIMETAIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLI
ISPEFASIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARL
DKVEQLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH
3D structure
PDB8kgq Structure of African swine fever virus topoisomerase II in complex with dsDNA
ChainB
Resolution5.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B D440 G472 V473 D543 R705 Q706 T715 H753 A850 N851 P852 D438 G470 V471 D541 R703 Q704 T713 H751 A848 N849 P850
BS02 dna B K547 K661 R799 Y800 P852 S853 E854 G855 W856 K857 R1004 H1010 H1012 K545 K659 R797 Y798 P850 S851 E852 G853 W854 K855 R1002 H1008 H1010
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgq, PDBe:8kgq, PDBj:8kgq
PDBsum8kgq
PubMed38816407
UniProtA0A2X0THW2

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