Structure of PDB 8kco Chain B

Receptor sequence

>8kcoB (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]

KYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETV
GQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLF
FFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAY
LIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETA
QERNETLFPALIYSSTRGVKLGLGDFIFYSVLVGKASATASGDWNTTIAC
FVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQL
AFHQFYI

3D structure

PDB

8kco CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560

Chain

Resolution

2.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	N60	B	V272 K380 G382 D385 K429 K430 L432	V197 K220 G222 D225 K269 K270 L272

External links

PDB	RCSB:8kco, PDBe:8kco, PDBj:8kco
PDBsum	8kco
PubMed
UniProt	P49768\|PSN1_HUMAN Presenilin-1 (Gene Name=PSEN1)

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