Structure of PDB 8k5v Chain B

Receptor sequence
>8k5vB (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
NLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELD
SATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVI
DDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGL
LAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHEFGHALGLDHS
SVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG
3D structure
PDB8k5v Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.35: gelatinase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C99 H226 H230 H236 C62 H189 H193 H199
BS02 ZN B H175 D177 H190 H203 H138 D140 H153 H166
BS03 CA B D182 G183 D185 L187 D205 E208 D145 G146 D148 L150 D168 E171
BS04 CA B D131 D206 E208 D94 D169 E171
BS05 CA B D165 G197 Q199 D201 D128 G160 Q162 D164
BS06 2HP B T157 R158 T120 R121
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k5v, PDBe:8k5v, PDBj:8k5v
PDBsum8k5v
PubMed37952596
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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