Structure of PDB 8jxn Chain B

Receptor sequence

>8jxnB (length=520) Species: 9606 (Homo sapiens)

YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKQGTIGGADLHCRKSGVSDHWALDDHHALHLTRKVVRN
LNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSR
FTEFKAFYGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQ
RNIPLLFLQNITGFMVGREYEAEGIAKDGAKMVAAVACAQVPKITLIIGG
SYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQRARE
GKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGL
SFSAALNAPIEKTDFGIFRM

3D structure

• PDB: 8jxn Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with substrate
• Chain: B
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BTI	B	T405 G406 F407 V409 Y445 G446 M473	T362 G363 F364 V366 Y402 G403 M430
BS02	TW3	B	R78 K141 G142 G174 A176 Y177 F185 T217 A218	R56 K119 G120 G152 A154 Y155 F163 T195 A196
BS03	TW3	B	I485 Q489	I442 Q446

Gene Ontology

Molecular Function

• GO:0004485 methylcrotonoyl-CoA carboxylase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016874 ligase activity

Biological Process

• GO:0006552 L-leucine catabolic process
• GO:0009083 branched-chain amino acid catabolic process
• GO:0015936 coenzyme A metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005829 cytosol
• GO:1905202 methylcrotonoyl-CoA carboxylase complex

External links

• PDB: RCSB:8jxn, PDBe:8jxn, PDBj:8jxn
• PDBsum: 8jxn
• UniProt: Q9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)