Structure of PDB 8jxj Chain B

Receptor sequence
>8jxjB (length=570) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESGLFLCPA
EGTCIPSSWVCDEDKDCSDGADEQQNCAKPTHKPCTDTEYKCSNGNCISQ
HYVCDNVNDCGDLSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRP
GFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHY
GERCAADGSPPLLLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDP
EHIGLSVVYYTVLAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQ
PDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVN
PKLGLMFWTDQGKQPKIESAWMNGEHRSVLVSENLGWPNGLSIDYLNDDR
VYWSDSKEDVIEAIKYDGTDRRLIINEAMKPFSLDIFEDKLYWVAKEKGE
VWRQNKFGKENKEKVLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCL
LRPGGYSCACPQGSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDE
NELPKCKCSSGYSGEYCEVG
3D structure
PDB8jxj Cryo-EM structures elucidate the multiligand receptor nature of megalin.
ChainB
Resolution3.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B W45 D48 T50 D52 D58 E59 W19 D22 T24 D26 D32 E33
BS02 CA B W85 D88 D90 D92 D98 E99 W59 D62 D64 D66 D72 E73
BS03 CA B Y3947 D3950 V3952 D3954 D3960 E3961 Y102 D105 V107 D109 D115 E116
BS04 CA B D4009 I4010 E4012 N4025 S4026 G4028 S4029 D164 I165 E167 N180 S181 G183 S184
External links
PDB RCSB:8jxj, PDBe:8jxj, PDBj:8jxj
PDBsum8jxj
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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