Structure of PDB 8juw Chain B

Receptor sequence
>8juwB (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGT
GKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAY
QMRPSIIFFDQIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVI
GATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLD
TFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSS
INISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQ
RVFPHAEFYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDI
PVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATF
TTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRDYGEIFNVQLPDKE
ERTKFFEDLILKQAAKPPIHERLKNLLKTVVKKSQNYNIFQLENLYAVIS
QCIYRHRKDHDKTSLIQKMEQEVENFSCS
3D structure
PDB8juw Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
ChainB
Resolution3.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ATP B S427 G429 P469 G470 T471 G472 K473 T474 L475 K640 S6 G8 P48 G49 T50 G51 K52 T53 L54 K219
BS02 ATP B R586 R589 R165 R168
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:8juw, PDBe:8juw, PDBj:8juw
PDBsum8juw
PubMed37770645
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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