Structure of PDB 8jh3 Chain B

Receptor sequence
>8jh3B (length=1155) Species: 460519 (Komagataella phaffii) [Search protein sequence]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSP
VYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKECPY
DMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALEKG
SRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPDGE
ILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGIRR
EKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERKDQ
DDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFNLN
LAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHL
RRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGI
SIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSM
LVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDES
KDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETIMI
AMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIP
FPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAKTQ
AMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFR
SYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRVSG
DDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGLKFVKVR
MRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPHAI
PSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQSR
GFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLTRQ
PVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVHVCGICG
LMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMNIAPRLY
TERSG
3D structure
PDB8jh3 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
ChainB
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B A470 G471 Q474 P521 Q776 R884 H887 K979 K987 H1097 R1124 A432 G433 Q436 P483 Q719 R827 H830 K912 K920 H1030 R1057
BS02 dna B D498 T791 M792 R1122 R1129 D460 T734 M735 R1055 R1062
BS03 ZN B C1163 C1166 C1182 C1185 C1096 C1099 C1115 C1118
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jh3, PDBe:8jh3, PDBj:8jh3
PDBsum8jh3
PubMed37981206
UniProtC4QZQ7

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