Structure of PDB 8jgj Chain B

Receptor sequence

>8jgjB (length=684) Species: 10090 (Mus musculus) [Search protein sequence]

GVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWL
VVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSKCPQ
WKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGS
GIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVA
CCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEE
VSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFE
LFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITA
VIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRIPDRPAGVGVYSAI
WQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAY
YHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTH
TTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKES
QRLVGFALRRDLTIAIESARKKVCFAQLKLRSILDMSPFTVTDHTPMEIV
VDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMA

3D structure

PDB

8jgj Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	H89 A668 Y689 N690 G691 I794 T796 K798 D799 R802	H9 A568 Y589 N590 G591 I673 T675 K677 D678 R681
BS02	CL	B	S239 Y630	S150 Y530

External links

PDB	RCSB:8jgj, PDBe:8jgj, PDBj:8jgj
PDBsum	8jgj
PubMed	39107281
UniProt	P51791\|CLCN3_MOUSE H(+)/Cl(-) exchange transporter 3 (Gene Name=Clcn3)

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