Structure of PDB 8jf3 Chain B

Receptor sequence
>8jf3B (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
DAWEIPRESLEVKLGGEVWMGTWNGTTRVAIKTLAQVMKKLRHEKLVQLY
AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY
VERMNYVHRDLRAANILVGENLVCKVADFPIKWTAPEAALYGRFTIKSDV
WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM
CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB8jf3 Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.
ChainB
Resolution2.84648 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C0N B L276 G277 V284 A296 K298 E342 Y343 M344 S345 K346 G347 L396 L14 G15 V18 A30 K32 E63 Y64 M65 S66 K67 G68 L117
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8jf3, PDBe:8jf3, PDBj:8jf3
PDBsum8jf3
PubMed38248139
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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