Structure of PDB 8jem Chain B

Receptor sequence

>8jemB (length=419) Species: 264199 (Streptococcus thermophilus LMG 18311)

FQGSMIDFLKQLPHLEPYGNPFYFIYLGIALLPIFIGLFFKKRFAIYECL
VSITFIVLALTGTHASQILALLFYIVWQIIWVYSYKRYRSQRDNKWVFYL
HSFLVVLPLILVKVEPTINGTQSLLNFLGISYLTFRAVGMIIEMRDGVLK
EFTLGEFLRFMLFMPTFTSGPIDRFKRFNEDYQSIPNRDELLNMLEQAVK
YIMLGFLYKFVLAQIFGSMLLPPLKAQALSQGGIFNLPTLGVMYVYGFDL
FFDFAGYSMFALAVSNLMGIKSPINFDKPFISRDMKEFWNRWHMSLSFWF
RDFVFMRLVIVLMRNKVFKNRNTTSNVAYIINMMVMGFWHGITWYYIAYG
IFHGIGLVINDAWLRKKKTINKDRKKAGLKPLPENKWTKALGIFITFNTV
MLSFLIFSGFLNDLWFTKK

3D structure

• PDB: 8jem Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation.
• Chain: B
• Resolution: 3.23 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PGT	B	L28 F36	L32 F40
BS02	ASW	B	Y128 S165 Y242 L246 D249 F250 W285 W288 H336 Y345	Y132 S169 Y246 L250 D253 F254 W289 W292 H340 Y349
BS03	PGT	B	Y95 V102 V110 F131 I138 R141 W295 V307 F334 I338	Y99 V106 V114 F135 I142 R145 W299 V311 F338 I342
BS04	PGT	B	C45 I49 L68 I71 R83 E147 L150	C49 I53 L72 I75 R87 E151 L154

Gene Ontology

Molecular Function

• GO:0016746 acyltransferase activity

Biological Process

• GO:0070395 lipoteichoic acid biosynthetic process

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:8jem, PDBe:8jem, PDBj:8jem
• PDBsum: 8jem
• PubMed: 38649359
• UniProt: Q5M4V4|DLTB_STRT2 Teichoic acid D-alanyltransferase (Gene Name=dltB)