Structure of PDB 8jby Chain B

Receptor sequence
>8jbyB (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
KLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR
VKLSNVDCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVH
NIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF
KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPG
AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHM
VQTECQYVYLHQCVRDVLRARK
3D structure
PDB8jby Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.
ChainB
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U7L B D1870 H1871 C1904 S1905 A1906 V1908 G1909 R1910 H1945 Q1948 D174 H175 C208 S209 A210 V212 G213 R214 H249 Q252
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jby, PDBe:8jby, PDBj:8jby
PDBsum8jby
PubMed37414577
UniProtP23467|PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Gene Name=PTPRB)

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