Structure of PDB 8jar Chain B

Receptor sequence
>8jarB (length=573) Species: 9606 (Homo sapiens) [Search protein sequence]
EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQL
GSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCS
YIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEM
LHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKA
ALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKAC
VVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQ
SVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFH
AERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEA
HDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAI
QIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLF
GEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDA
LEDVSTSPQSTEEVVQSFLISQN
3D structure
PDB8jar Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y338 Y341 V342 Y345 S377 R380 V381 E387 K430 R437 Q440 S441 L472 H476 S479 Y483 Y515 Y332 Y335 V336 Y339 S371 R374 V375 E381 K424 R431 Q434 S435 L466 H470 S473 Y477 Y509
BS02 ZN B C54 H89 C48 H83
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jar, PDBe:8jar, PDBj:8jar
PDBsum8jar
PubMed37844242
UniProtQ92624|APBP2_HUMAN Amyloid protein-binding protein 2 (Gene Name=APPBP2)

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