Structure of PDB 8j99 Chain B

Receptor sequence

>8j99B (length=514) Species: 9606 (Homo sapiens)

YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKK
LDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKA
FYGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLL
FLQNITGFMVGREYEAEGIAKDGAKMVAAVACAQVPKITLIIGGSYGAGN
YGMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQRAREGKQFSS
ADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGLSFSAAL
NAPIEKTDFGIFRM

3D structure

• PDB: 8j99 Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state
• Chain: B
• Resolution: 2.87 Å

Enzymatic activity

• Enzyme Commision number: 6.4.1.4: methylcrotonoyl-CoA carboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TW3	B	R78 K141 G142 G174 A176 Y177 L178	R56 K119 G120 G152 A154 Y155 L156

Gene Ontology

Molecular Function

• GO:0004485 methylcrotonoyl-CoA carboxylase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016874 ligase activity

Biological Process

• GO:0006552 L-leucine catabolic process
• GO:0009083 branched-chain amino acid catabolic process
• GO:0015936 coenzyme A metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005829 cytosol
• GO:1905202 methylcrotonoyl-CoA carboxylase complex

External links

• PDB: RCSB:8j99, PDBe:8j99, PDBj:8j99
• PDBsum: 8j99
• UniProt: Q9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)