Structure of PDB 8j74 Chain B

Receptor sequence
>8j74B (length=515) Species: 9606 (Homo sapiens) [Search protein sequence]
FHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLL
VGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFF
AKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGAT
ISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWIS
VPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGI
PWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQ
TAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSI
LSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTV
YGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEP
YLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLF
ESGTLPPKLDVFDAV
3D structure
PDB8j74 Transport mechanism of presynaptic high-affinity choline uptake by human CHT1
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AV0 B I215 G216 F217 H221 I213 G214 F215 H219
BS02 AV0 B F205 S208 H209 C328 P329 F203 S206 H207 C326 P327
BS03 HC6 B W62 Y91 W141 L247 W254 W406 Y407 S410 W60 Y89 W139 L245 W252 W404 Y405 S408
Gene Ontology
Molecular Function
GO:0005307 choline:sodium symporter activity
GO:0015220 choline transmembrane transporter activity
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
GO:0033265 choline binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006814 sodium ion transport
GO:0006836 neurotransmitter transport
GO:0007271 synaptic transmission, cholinergic
GO:0007274 neuromuscular synaptic transmission
GO:0008292 acetylcholine biosynthetic process
GO:0015871 choline transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030672 synaptic vesicle membrane
GO:0031594 neuromuscular junction
GO:0031901 early endosome membrane
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j74, PDBe:8j74, PDBj:8j74
PDBsum8j74
PubMed38589607
UniProtQ9GZV3|SC5A7_HUMAN High affinity choline transporter 1 (Gene Name=SLC5A7)

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