Structure of PDB 8izc Chain B

Receptor sequence
>8izcB (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESK
IYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKT
VLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAK
KYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLM
YFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNF
CRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB8izc The Discovery of BMS-986164, a Potent, Selective and Orally Efficacious CK1d/e/a Inhibitor from Pyrazolo-Piperazine Chemotype
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S93 B I15 I23 A36 K38 M82 L84 L85 G86 L135 I11 I19 A32 K34 M78 L80 L81 G82 L131
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8izc, PDBe:8izc, PDBj:8izc
PDBsum8izc
PubMed
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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