Structure of PDB 8it0 Chain B

Receptor sequence
>8it0B (length=450) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]
MRNKIFISHATPEDDDFTRWLSLKLIGLGYEVWCDILFLDKGVDFWSTIE
KEIRENTCKFLIVSSTAGNKREGVLKELAVATKVKKHLQDDMFIIPLAID
ENLSYDDINIEIVRLNAIDFKKSWAKGLQDLLDAFEKQNVPKKPPDHSKS
NLLYQQIFLHDKQAIEKEETYDSNWFPIISFPNELRFHRYDWRLPKQFDV
RTLAFPAIRYKEYLCTFAWEYDFIHQLPKTETYNGQESIRISTSDILSGR
YDTDFIRNYECQRLIVQLINKAFELRMKDKNVREYQMSKTFAYWIEKGKL
EKDKFEKIKLVGKQKNKYWHFGISAAGKLYPSPVLMVSSHIIFTMDGINL
IKSKSIQHSSRRKQGKNWWNDKWREKLLAFIRFLSDDQNAIYLNVGSEEK
ILISNKPLKFFGKMSYVTPSEVTLEEESVLADINNFEEDTEDLDELEDIE
3D structure
PDB8it0 Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R201 K289 S355 H358 K363 K366 N434 N435 E441 E445 L446 R201 K289 S355 H358 K363 K366 N434 N435 E441 E445 L446
BS02 rna B K196 H340 K354 H358 R361 R362 N434 E437 E438 K196 H340 K354 H358 R361 R362 N434 E437 E438
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:8it0, PDBe:8it0, PDBj:8it0
PDBsum8it0
PubMed37783228
UniProtA0A1I7NFG5

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