Structure of PDB 8is0 Chain B

Receptor sequence
>8is0B (length=373) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HMVMLAQQWRDARPKVAGLHLDSGACSRQSFAVIDATTAHARHEAEVGGY
VAAEAATPALDAGRAAVASLIGFAASDVVYTSGSNHAIDLLLSSWPGKRT
LACLPGEFGPNLSAMAANGFQVRALPVDDDGRVLVDEASHELSAHPVALV
HLTALASHRGIAQPAAELVEACHNAGIPVVIDAAQALGHLDCNVGADAVY
SSSRKWLAGPRGVGVLAVRPELAERLQPRIPPSDWPIPMSVLEKLELGEH
NAAARVGFSVAVGEHLAAGPTAVRERLAEVGRLSRQVLAEVDGWRVVEPV
DQPTAITTLESTDGADPASVRSWLIAERGIVTTACELARAPFEMRTPVLR
ISPHVDVTVDELEQFAAALREAP
3D structure
PDB8is0 Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE.
ChainB
Resolution3.02 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G81 S82 N83 F106 S155 D180 A182 Q183 S200 R202 K203 G83 S84 N85 F108 S157 D182 A184 Q185 S202 R204 K205
BS02 DHA B A23 R202 K203 R337 R348 A25 R204 K205 R339 R350
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:1990411 hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8is0, PDBe:8is0, PDBj:8is0
PDBsum8is0
PubMed38072054
UniProtA0R5M7|EGTE_MYCS2 Probable hercynylcysteine sulfoxide lyase (Gene Name=egtE)

[Back to BioLiP]