Structure of PDB 8irk Chain B

Receptor sequence
>8irkB (length=373) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HMMMLAQQWRDARPKVAGLHLDSGACSRQSFAVIDATTAHARHEAEVGGY
VAAEAATPALDAGRAAVASLIGFAASDVVYTSGSNHAIDLLLSSWPGKRT
LACLPGEYGPNLSAMAANGFQVRALPVDDDGRVLVDEASHELSAHPVALV
HLTALASHRGIAQPAAELVEACHNAGIPVVIDAAQALGHLDCNVGADAVY
SSSRKWLAGPRGVGVLAVRPELAERLQPRIPPSDWPIPMSVLEKLELGEH
NAAARVGFSVAVGEHLAAGPTAVRERLAEVGRLSRQVLAEVDGWRVVEPV
DQPTAITTLESTDGADPASVRSWLIAERGIVTTACELARAPFEMRTPVLR
ISPHVDVTVDELEQFAAALREAP
3D structure
PDB8irk Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G81 S82 N83 Y106 S155 D180 A182 S200 R202 K203 G83 S84 N85 Y108 S157 D182 A184 S202 R204 K205
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:1990411 hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:8irk, PDBe:8irk, PDBj:8irk
PDBsum8irk
PubMed38072054
UniProtA0R5M7|EGTE_MYCS2 Probable hercynylcysteine sulfoxide lyase (Gene Name=egtE)

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