Structure of PDB 8ipx Chain B

Receptor sequence

>8ipxB (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]

SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKA
GMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRT
FKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFS
SMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERL
EQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKV
ACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSL
LVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEE
GA

3D structure

PDB

8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

4.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	S2 H3 R4 S7 P9 R10 H11 G12 S13 F16 L17 P18 R19 K20 R21 H25 R26 K28 K30 S31 M53 T54 H55 R62 S65 A75 Y92 T95 P96 R97 L99 R100 T101 F102 T104 R116 R117 Y119 K120 H123 K127 K128 F130 K132 Y133 Y156 R161 R174 Q175 K176 K177 E182 K224 G225 Y228 G230 K238 K239 R242 K243 G247 R249 K250 A252 C253 A256 W257 H258 A260 R261 V262 S265 R268 A269 Q271 H276 R277 T278 E279 I280 L317 G318 H322 G324 K334 C336 V337 T340 K341 K342 R343 R357 S372 K373 F374 H376 K385 M389 L392 K393 R396	S1 H2 R3 S6 P8 R9 H10 G11 S12 F15 L16 P17 R18 K19 R20 H24 R25 K27 K29 S30 M52 T53 H54 R61 S64 A74 Y91 T94 P95 R96 L98 R99 T100 F101 T103 R115 R116 Y118 K119 H122 K126 K127 F129 K131 Y132 Y155 R160 R173 Q174 K175 K176 E181 K223 G224 Y227 G229 K237 K238 R241 K242 G246 R248 K249 A251 C252 A255 W256 H257 A259 R260 V261 S264 R267 A268 Q270 H275 R276 T277 E278 I279 L316 G317 H321 G323 K333 C335 V336 T339 K340 K341 R342 R356 S371 K372 F373 H375 K384 M388 L391 K392 R395

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0071353	cellular response to interleukin-4

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
PDBsum	8ipx
PubMed	37491604
UniProt	P39023\|RL3_HUMAN Large ribosomal subunit protein uL3 (Gene Name=RPL3)

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