Structure of PDB 8imz Chain B

Receptor sequence
>8imzB (length=1223) Species: 10090 (Mus musculus) [Search protein sequence]
LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLV
VLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQIQNHLQILLLLVFEA
VVYRRQEHYRRQHRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIG
QRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLG
MNSALIKWLYLPPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRGEPNP
IPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACF
YLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFCWVIQ
LFSLIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAA
NLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASDHATVIHSGDY
FLFESDSEEGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVG
EVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVA
AHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAI
VFTEVMVVTKYLFQFGFFPPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFQV
PQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILP
AVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNH
LNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIK
CSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSV
VGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPY
PLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADIT
LRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSV
VIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGGTKAS
DFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIV
LVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEE
LYAKLIFLYRSPETMIKWTRERE
3D structure
PDB8imz MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.
ChainB
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H2116 F2120 Q2123 L2127 S2168 R2169 K2184 V2187 M2191 E2495 H800 F804 Q807 L811 S852 R853 K868 V871 M875 E1171
Gene Ontology
Molecular Function
GO:0005261 monoatomic cation channel activity
GO:0005515 protein binding
GO:0008381 mechanosensitive monoatomic ion channel activity
GO:0042802 identical protein binding
GO:0140135 mechanosensitive monoatomic cation channel activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0010831 positive regulation of myotube differentiation
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050982 detection of mechanical stimulus
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031258 lamellipodium membrane
GO:0032420 stereocilium
GO:0032437 cuticular plate
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8imz, PDBe:8imz, PDBj:8imz
PDBsum8imz
PubMed37590348
UniProtE2JF22|PIEZ1_MOUSE Piezo-type mechanosensitive ion channel component 1 (Gene Name=Piezo1)

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