Structure of PDB 8img Chain B

Receptor sequence
>8imgB (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLS
YYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRENPLSQFL
EGEILSASKMLSKFRKIIKEEIDIVIMKRKRGSAVTLLISEISVDITLAL
ESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKGFQEETWRL
SFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDK
KHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRT
EKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB8img Discovery of novel cGAS inhibitors based on natural flavonoids.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7XZ B K362 R376 L377 S434 Y436 H437 N482 I485 K188 R199 L200 S257 Y259 H260 N305 I308
BS02 ZN B H390 C396 C397 C404 H213 C219 C220 C227
External links
PDB RCSB:8img, PDBe:8img, PDBj:8img
PDBsum8img
PubMed37666112
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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