Structure of PDB 8imf Chain B

Receptor sequence
>8imfB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDSTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNY
EHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNENPLSQFLE
GEILSASKMLSKFRKIIKEEINDIDVIMKRKGSPAVTLLISEKISVDITL
ALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKFQEETWR
LSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKD
KKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLR
TEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB8imf Discovery of novel cGAS inhibitors based on natural flavonoids.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3WL B A247 R376 Y436 N482 F488 L490 A82 R200 Y260 N306 F312 L314
BS02 ZN B H390 C396 C397 C404 H214 C220 C221 C228
External links
PDB RCSB:8imf, PDBe:8imf, PDBj:8imf
PDBsum8imf
PubMed37666112
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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