Structure of PDB 8ime Chain B

Receptor sequence
>8imeB (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNSYYEH
VKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFENPLSQFEGEILSA
SKMLSKFRKIIKEEINDDVIMKRKPAVTLLIEKISVDITLALESKSSWPA
STQEGLRIQNWLSAKVRKQLRLKPFYLVPKHFQEETWRLSFSHIEKEILN
NHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHV
KTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEF
NLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
3D structure
PDB8ime Discovery of novel cGAS inhibitors based on natural flavonoids.
ChainB
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0XE B V218 R376 S380 K432 S434 Y436 H437 K439 V51 R188 S192 K244 S246 Y248 H249 K251
BS02 ZN B H390 C396 C397 C404 H202 C208 C209 C216
External links
PDB RCSB:8ime, PDBe:8ime, PDBj:8ime
PDBsum8ime
PubMed37666112
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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