Structure of PDB 8im3 Chain B

Receptor sequence
>8im3B (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
KGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSRE
VVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYI
VQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQF
LPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQF
HRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYV
DYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTA
KIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNH
QGFGAGNFNSLFKAFEEEQNLR
3D structure
PDB8im3 Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.
ChainB
Resolution2.78 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO B H183 H266 E349 H177 H260 E343
BS02 92U B P239 Q251 H266 F336 F359 G360 N363 F364 L367 P233 Q245 H260 F330 F353 G354 N357 F358 L361
Gene Ontology
Molecular Function
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0009072 aromatic amino acid metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8im3, PDBe:8im3, PDBj:8im3
PDBsum8im3
PubMed37794595
UniProtP32754|HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)

[Back to BioLiP]