Structure of PDB 8ijv Chain B

Receptor sequence
>8ijvB (length=268) Species: 9823 (Sus scrofa) [Search protein sequence]
NPDTGQMLGRTLSRWVWISLYYVAFYVVMSGIFALCIYVLMRTIDPYTPD
YQDQLKSPGVTLRPDVYGEKGLDISYNVSDSTTWAGLAHTLHRFLAGYSP
AAQEGSINCTSEKYFFQESFLAPNHTKFSCKFTADMLQNCSGRPDPTFGF
AEGKPCFIIKMNRIVKFLPGNSTAPRVDCAFLDQPRDGPPLQVEYFPANG
TYSLHYFPYYGKKAQPHYSNPLVAAKLLNVPRNRDVVIVCKILAEHVSFD
NPHDPYEGKVEFKLKIQK
3D structure
PDB8ijv Deep learning driven de novo drug design based on gastric proton pump structures.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR B W39 A46 W17 A24
BS02 CLR B R32 I40 S41 Y44 Y48 R10 I18 S19 Y22 Y26
Gene Ontology
Molecular Function
GO:0001671 ATPase activator activity
GO:0005515 protein binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0007155 cell adhesion
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016324 apical plasma membrane

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Cellular Component
External links
PDB RCSB:8ijv, PDBe:8ijv, PDBj:8ijv
PDBsum8ijv
PubMed37726448
UniProtP18434|ATP4B_PIG Potassium-transporting ATPase subunit beta (Gene Name=ATP4B)

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