Structure of PDB 8ijr Chain B

Receptor sequence
>8ijrB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
RLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDS
VPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLR
CFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTC
GDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHE
HYSIDVFIAFYITTRLFLYYHTLANTRAYQQSRRARIWFPMFSFFECNVN
GTVPNEYCWPFSKP
3D structure
PDB8ijr Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
ChainB
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z0P B F163 M170 L232 M285 H301 F20 M27 L89 M142 H158
BS02 OPE B M170 H291 C293 G294 M27 H148 C150 G151
Gene Ontology
Molecular Function
GO:0002950 ceramide phosphoethanolamine synthase activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0033188 sphingomyelin synthase activity
GO:0047493 ceramide cholinephosphotransferase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006686 sphingomyelin biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:1905373 ceramide phosphoethanolamine biosynthetic process
GO:2000303 regulation of ceramide biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ijr, PDBe:8ijr, PDBj:8ijr
PDBsum8ijr
PubMed38388831
UniProtQ96LT4|SAMD8_HUMAN Sphingomyelin synthase-related protein 1 (Gene Name=SAMD8)

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